EFNA3 Gene Summary [Human]
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EFNA3 |
| Official Name | ephrin A3 [Source:HGNC Symbol;Acc:HGNC:3223] |
| Ensembl ID | ENSG00000143590 |
| Bio databases IDs | |
| Aliases | ephrin A3, EPH-related receptor tyrosine kinase ligand 3 |
| Synonyms | AW494418, EFL-2, Ehk1-L, EHK1 ligand, EPHRIN A3, Epl3, EPLG3, LERK-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EFNA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- transmembrane-ephrin receptor
- Ephrin
- Cupredoxin superfamily
- ephrin receptor binding
- protein binding
- hydrophobic domain
Pathways
Biological processes and signaling networks where the EFNA3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- nonalcoholic fatty liver disease
- papillary thyroid carcinoma
- papillary thyroid cancer
role in cell
- expression in
- phosphorylation in
- survival
- induction in
- migration
- invasion by
- sphere formation
- motility
- number
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EFNA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- ephrin receptor signaling pathway
- cell-cell signaling
- axon guidance
- regulation of neuron differentiation
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ephrin receptor binding
- transmembrane-ephrin receptor activity