Slc20a1 Gene Summary [Mouse]
Predicted to enable high-affinity phosphate:sodium symporter activity. Acts upstream of or within biomineral tissue development. Located in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; submandibular gland primordium; and yolk sac. Orthologous to human SLC20A1 (solute carrier family 20 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc20a1 |
| Official Name | solute carrier family 20, member 1 [Source:MGI Symbol;Acc:MGI:108392] |
| Ensembl ID | ENSMUSG00000027397 |
| Bio databases IDs | |
| Aliases | solute carrier family 20, member 1 |
| Synonyms | GLVR1, leukaemia Virus Receptor, NaPi3, PIT1, Rpho1, solute carrier family 20 member 1, SOLUTE CARRIER family 20, member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc20a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high affinity inorganic phosphate:sodium symporter
- signaling receptor activity
- sodium:phosphate symporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- aortic valve calcification
- anemia
- hypoplasia
- growth failure
- infection
role in cell
- expression in
- number
- phosphorylation in
- apoptosis
- proliferation
- binding
- cell cycle progression
- mitosis
- mineralization
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc20a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- ion transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- sodium ion transmembrane transport
- phosphate-containing compound metabolic process
- phosphate ion transmembrane transport
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- high affinity inorganic phosphate:sodium symporter activity
- inorganic phosphate transmembrane transporter activity
- sodium:phosphate symporter activity
- signaling receptor activity