ARPC2 Gene Summary [Human]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
ARPC2
Official Name
actin related protein 2/3 complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:705]
Ensembl ID
ENSG00000163466
Bio databases IDs NCBI: 10109 Ensembl: ENSG00000163466
Aliases actin related protein 2/3 complex subunit 2
Synonyms 2210023N03Rik, actin related protein 2/3 complex subunit 2, actin related protein 2/3 complex, subunit 2, ARC34, Arp2, Arp2/3, Arpc2 predicted, p34, p34-Arc, PNAS-139, PRO2446
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARPC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • actin filament binding
  • ATPase binding
  • binding protein
  • structural constituent of cytoskeleton
  • Arp2/3 complex, 34 kD subunit p34-Arc
  • protein binding
  • receptor binding
  • kinesin binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • Pyoderma gangrenosum
  • colorectal cancer
  • ulcerative colitis
regulated by
regulates
  • RHOA
  • F Actin
  • ACTIN
  • ARPC2
  • actin
  • Myelin
  • zymosan
role in cell
  • formation
  • survival
  • phagocytosis
  • migration
  • morphology
  • polymerization
  • number
  • quantity
  • extension
  • sum total

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • synaptic vesicle membrane
  • glutaminergic synapse
  • invadopodia
  • presynaptic regions
  • cell surface
  • cell periphery
  • postsynaptic region
  • focal complexes
  • focal adhesions
  • actin cytoskeleton
  • Nucleus
  • Plasma Membrane
  • intracellular storage compartment
  • endosomes
  • Mitochondria
  • actin filaments
  • cytosol
  • membrane ruffles
  • nucleoplasm
  • sperm head
  • dendritic spines
  • growth cone
  • synapse
  • late endosomes
  • membrane blebs
  • actin tails
  • anchoring junction
  • secretory granules
  • cellular protrusions
  • cell membrane leading edge
  • perikaryon
  • axon terminals
  • dendritic shafts
  • exosomes
  • cell-cell adherens junctions
  • dense core granules
  • lamellipodia
  • apical processes

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human ARPC2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of lamellipodium assembly
  • actin filament polymerization
  • positive regulation of actin filament polymerization
  • Arp2/3 complex-mediated actin nucleation
  • actin polymerization-dependent cell motility
  • positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

Where in the cell the gene product is active
  • site of double-strand break
  • muscle cell projection membrane
  • neuron projection
  • nucleoplasm
  • Arp2/3 protein complex
  • nucleus
  • extracellular vesicular exosome
  • endosome
  • focal adhesion
  • actin cytoskeleton
  • cytosol
  • lamellipodium

Molecular Function

What the gene product does at the molecular level
  • actin filament binding
  • protein binding
  • structural constituent of cytoskeleton

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.