TMEM108 Gene Summary [Human]
Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in axon; endosome; and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | TMEM108 |
| Official Name | transmembrane protein 108 [Source:HGNC Symbol;Acc:HGNC:28451] |
| Ensembl ID | ENSG00000144868 |
| Bio databases IDs | |
| Aliases | transmembrane protein 108, cancer/testis antigen 124 |
| Synonyms | AI462967, B130017P16Rik, CT124, RGD1311530, RTLN, transmembrane protein 108 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM108 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- TMEM108 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- somatodendritic region
- synaptic membrane
- endosomal membrane
- early endosomes
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM108 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of nerve growth factor receptor signaling pathway
- neuron projection development
- postsynaptic density organization
- receptor-mediated endocytosis
- retrograde axon cargo transport
- dentate gyrus development
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- early endosome
- endosome membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding