TIMD4 Gene Summary [Human]
Predicted to enable phosphatidylserine binding activity. Predicted to act upstream of or within apoptotic cell clearance. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TIMD4 |
| Official Name | T cell immunoglobulin and mucin domain containing 4 [Source:HGNC Symbol;Acc:HGNC:25132] |
| Ensembl ID | ENSG00000145850 |
| Bio databases IDs | |
| Aliases | T cell immunoglobulin and mucin domain containing 4 |
| Synonyms | B430010N18RIK, LOC91937, SMUCKLER, T cell immunoglobulin and mucin domain containing 4, TIM-4 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TIMD4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin variable domain
- immunoglobulin domain
- Immunoglobulin like
- mucin domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the TIMD4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiovascular disorder
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- hyperplasia
- Crohn disease
- aortic valve calcification
- inflammatory bowel disease
- primary genetic hyperlipidemia
role in cell
- activation
- proliferation
- phosphorylation in
- engulfment
- co-stimulation
- engulfment by
- phagocytosis by
- activation in
- autophagy in
- ingestion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TIMD4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeletal rearrangement involved in phagocytosis, engulfment
- apoptotic cell clearance
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding