SERPINB9
SERPINB9 Gene Summary
This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | SERPINB9 |
| Official Name | serpin family B member 9 [Source:HGNC Symbol;Acc:HGNC:8955] |
| Ensembl ID | ENSG00000170542 |
| Bio databases IDs | |
| Aliases | serpin family B member 9, cytoplasmic antiproteinase 3 |
| Synonyms | CAP-3,p19,PI-9,serpin family B member 9 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- caspase inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
- reactive serpin loop
Pathways
Biological processes and signaling networks where the SERPINB9 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TP53
- TRAF5
- ESR1
- CCT7
- CCT6A
- CCT3
- CCT2
- TUBB2A
- LMNA
- VCP
disease
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
regulated by
- tetradecanoylphorbol acetate
- IL1B
- TNF
- beta-estradiol
- lipopolysaccharide
- SB203580
- dexamethasone
- IFNG
- fulvestrant
- IL4
regulates
- IL1B
- IL18
- GZMB
- Protease
- CASP1
- ELANE
- caspase
- endopeptidase
- Apr
- cysteine protease
role in cell
- apoptosis
- inhibition in
- cell death
- blockade in
- protection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SERPINB9 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protection from natural killer cell mediated cytotoxicity
- immune response
- mast cell mediated immunity
- negative regulation of apoptotic process
- negative regulation of endopeptidase activity
- cellular response to estrogen stimulus
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- Golgi apparatus
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- protease binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process