PPP1R16B Gene Summary [Human]
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R16B |
| Official Name | protein phosphatase 1 regulatory subunit 16B [Source:HGNC Symbol;Acc:HGNC:15850] |
| Ensembl ID | ENSG00000101445 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory subunit 16B, TGF-beta-inhibited membrane-associated protein, ankyrin repeat domain protein 4 |
| Synonyms | ANKRD4, C130078N17RIK, LOC684098, protein phosphatase 1 regulatory subunit 16B, protein phosphatase 1, regulatory subunit 16B, TIMAP, Wdt4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R16B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- phosphatase
- Ankyrin repeats (3 copies)
- protein phosphatase regulator
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diverticular disease
- schizophrenia
- alcoholic pancreatitis
role in cell
- activation in
- phosphorylation in
- proliferation
- binding in
- differentiation
- survival
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- Nucleus
- plasma membrane projections
- nuclear speckles
- cellular protrusions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R16B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein kinase B signaling cascade
- regulation of filopodium assembly
- positive regulation of protein dephosphorylation
- negative regulation of protein dephosphorylation
- positive regulation of endothelial cell proliferation
- establishment of endothelial barrier
- regulation of protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- nuclear speck
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme inhibitor activity
- myosin phosphatase regulator activity
- protein phosphatase regulator activity