Igsf1 Gene Summary [Mouse]
Predicted to enable activin receptor antagonist activity; coreceptor activity; and inhibin binding activity. Predicted to be involved in immune response-regulating signaling pathway; negative regulation of activin receptor signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in extracellular region. Predicted to be active in membrane. Is expressed in several structures, including forebrain; liver; and medulla oblongata part of 4th ventricle choroid plexus. Used to study IGSF1 deficiency syndrome. Human ortholog(s) of this gene implicated in IGSF1 deficiency syndrome. Orthologous to human IGSF1 (immunoglobulin superfamily member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Igsf1 |
| Official Name | immunoglobulin superfamily, member 1 [Source:MGI Symbol;Acc:MGI:2147913] |
| Ensembl ID | ENSMUSG00000031111 |
| Bio databases IDs | |
| Aliases | immunoglobulin superfamily, member 1 |
| Synonyms | 5330413N23, 5530402E03, CHTE, IGCD1, IGDC1, immunoglobulin superfamily member 1, immunoglobulin superfamily, member 1, INHBP, InhBP/p120, mKIAA0364, p120, PGSF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Igsf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor antagonist activity
- immunoglobulin domain
- Immunoglobulin like
- protein binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- central hypothyroidism and testicular enlargement
- insomnia
- hereditary disorder
- weight gain
- Huntington disease
- thyroid carcinoma
- epithelial thyroid cancer
- heart failure
role in cell
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Igsf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response-regulating signaling pathway
- negative regulation of activin receptor signaling pathway
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- activin receptor antagonist activity
- protein binding
- inhibin binding