IFNK Gene Summary [Human]
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IFNK |
| Official Name | interferon kappa [Source:HGNC Symbol;Acc:HGNC:21714] |
| Ensembl ID | ENSG00000147896 |
| Bio databases IDs | |
| Aliases | interferon kappa |
| Synonyms | If1fa, IFN KAPPA, IFNT1, IFN κ, INFE1, INTERFERON-KAPPA, INTERFERON-κ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IFab
- interferon-alpha/beta receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the IFNK gene in human plays a role, providing insight into its function and relevance in health or disease.
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- hyperglycemia
role in cell
- phosphorylation in
- activation in
- expression in
- induction in
- apoptosis
- proliferation
- upregulation in
- differentiation
- production in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- negative regulation of cell proliferation
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- B cell proliferation
- adaptive immune response
- regulation of transcription, DNA-dependent
- response to virus
- T cell activation involved in immune response
- type I interferon-mediated signaling pathway
- natural killer cell activation involved in immune response
- positive regulation of innate immune response
- cytokine-mediated signaling pathway
- response to exogenous dsRNA
- humoral immune response
- defense response to virus
- natural killer cell activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interferon-alpha/beta receptor binding
- cytokine activity