Shc3 Gene Summary [Mouse]
Predicted to enable phosphotyrosine residue binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and liver and biliary system. Orthologous to human SHC3 (SHC adaptor protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shc3 |
| Official Name | src homology 2 domain-containing transforming protein C3 [Source:MGI Symbol;Acc:MGI:106179] |
| Ensembl ID | ENSMUSG00000021448 |
| Bio databases IDs | |
| Aliases | src homology 2 domain-containing transforming protein C3 |
| Synonyms | NSHC, Nsrc, RAI, SHC adaptor protein 3, SHCC, src homology 2 domain-containing transforming protein C3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- CH1 domain
- Src homology 2 (SH2) domain
- phosphotyrosine binding
- protein binding
- receptor binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- protein-tyrosine kinase
- Grb2 binding domain
Pathways
Biological processes and signaling networks where the Shc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Breast Cancer Regulation by Stathmin1
- CREB Signaling in Neurons
- Endothelin-1 Signaling
- Erythropoietin Signaling
- Estrogen Receptor Signaling
- G-Protein Coupled Receptor Signaling
- Glioblastoma Multiforme Signaling
- Gαi Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- NGF Signaling
- Renin-Angiotensin Signaling
- Role of NFAT in Cardiac Hypertrophy
- T Cell Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- neurological deficiency
- infarction
- Cornelia de Lange syndrome
- pemphigus vulgaris
role in cell
- expression in
- phosphorylation in
- growth
- loss
- differentiation
- apoptosis
- quantity
- survival
- signal transduction in
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- Plasma Membrane
- cytosol
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- epidermal growth factor receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- receptor tyrosine kinase binding