WIF1 Gene Summary [Human]
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | WIF1 |
| Official Name | WNT inhibitory factor 1 [Source:HGNC Symbol;Acc:HGNC:18081] |
| Ensembl ID | ENSG00000156076 |
| Bio databases IDs | |
| Aliases | WNT inhibitory factor 1 |
| Synonyms | WNT inhibitory factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WIF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt binding domain
- Wnt-protein binding
- protein binding
- WIF domain
Pathways
Biological processes and signaling networks where the WIF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- pituitary gland neoplasm
- head and neck neuroendocrine neoplasia
- adenoid cystic carcinoma of salivary gland
- salivary gland cancer
- epithelial cancer
- prostate cancer
- Alzheimer disease
- renal cell carcinoma
- renal cell cancer
role in cell
- expression in
- phosphorylation in
- apoptosis
- migration
- proliferation
- growth
- differentiation
- cell death
- transmembrane potential
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WIF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- blood vessel development
- signal transduction
- anterior/posterior pattern specification
- positive regulation of fat cell differentiation
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- determination of left/right symmetry
- nodal signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- nodal binding
- activin receptor binding
- Wnt-protein binding