PPP4C Gene Summary [Human]
Enables protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PPP4C |
| Official Name | protein phosphatase 4 catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9319] |
| Ensembl ID | ENSG00000149923 |
| Bio databases IDs | |
| Aliases | protein phosphatase 4 catalytic subunit, protein phosphatase X, catalytic subunit |
| Synonyms | 1110002D08Rik, pp2x-c, PP4, PP4C, PPH3, PPP4, PP-X, protein phosphatase 4 catalytic subunit, protein phosphatase 4, catalytic subunit |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP4C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- phosphatase
- lamin binding
- metallophosphatase superfamily, metallophosphatase domain
- Protein phosphatase 2A homologues, catalytic domain
- protein binding
- Calcineurin-like phosphoesterase
Pathways
Biological processes and signaling networks where the PPP4C gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- phosphorylation in
- survival
- production in
- binding in
- dephosphorylation in
- activation in
- serine phosphorylation in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pericentriolar regions
- Nucleus
- Plasma Membrane
- centrosome
- cytosol
- nucleoplasm
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP4C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of double-strand break repair
- double-strand break repair via homologous recombination
- regulation of double-strand break repair via homologous recombination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- protein phosphatase 4 complex
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity