LCMT1 Gene Summary [Human]
LCMT1 catalyzes the methylation of the carboxyl group of the C-terminal leucine residue (leu309) of the catalytic subunit of protein phosphatase-2A (PPP2CA; MIM 176915) (De Baere et al., 1999 [PubMed 10600115]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | LCMT1 |
| Official Name | leucine carboxyl methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17557] |
| Ensembl ID | ENSG00000205629 |
| Bio databases IDs | |
| Aliases | leucine carboxyl methyltransferase 1, protein phosphatase methyltransferase 1, [phosphatase 2A protein]-leucine-carboxy methyltransferase |
| Synonyms | CGI-68, LCMT, leucine carboxyl methyltransferase 1, PPMT1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LCMT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein methyltransferase
- C-terminal protein carboxyl methyltransferase
- protein-leucine O-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- androgenic alopecia
role in cell
- cell death
- long-term potentiation in
- phosphorylation in
- apoptosis
- phagocytosis by
- methylation in
- cohesion
- cohesion in
- loss in
- G2/M phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LCMT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- G2/M transition of mitotic cell cycle
- regulation of glucose metabolic process
- regulation of mitotic cell cycle spindle assembly checkpoint
- C-terminal protein methylation
- negative regulation of protein complex assembly
- regulation of apoptotic process
- protein methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein C-terminal carboxyl O-methyltransferase activity
- S-adenosylmethionine-dependent methyltransferase activity
- protein C-terminal leucine carboxyl O-methyltransferase activity