RNF144A Gene Summary [Human]
This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | RNF144A |
| Official Name | ring finger protein 144A [Source:HGNC Symbol;Acc:HGNC:20457] |
| Ensembl ID | ENSG00000151692 |
| Bio databases IDs | |
| Aliases | ring finger protein 144A |
| Synonyms | hUIP4, KIAA0161, RGD1561737, ring finger protein 144A, RNF144, UBCE7IP4, UIP4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF144A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IBR domain, a half RING-finger domain
- In Between Ring fingers
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- BRcat_Rcat_RBR
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- pervasive developmental disorder
- flu
- febrile seizure
- chronic obstructive asthma
- myopia
- cerebral aneurysm
- cerebral amyloid angiopathy
- Wegener granulomatosis
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Golgi Apparatus
- endoplasmic reticulum membrane
- endosomal membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF144A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- protein K6-linked ubiquitination
- pattern recognition receptor signaling pathway
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ubiquitin ligase complex
- cytoplasm
- intracellular membrane-bounded organelle
- endosome membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin conjugating enzyme binding
- zinc ion binding
- protein binding