GPR180 Gene Summary [Human]

This gene encodes a protein that is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
GPR180
Official Name
G protein-coupled receptor 180 [Source:HGNC Symbol;Acc:HGNC:28899]
Ensembl ID
ENSG00000152749
Bio databases IDs NCBI: 160897 Ensembl: ENSG00000152749
Aliases G protein-coupled receptor 180, intimal thickness related receptor
Synonyms E130016I23Rik, G protein-coupled receptor 180, ITR, LOC144874
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR180 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Lung seven transmembrane receptor

Pathways

Biological processes and signaling networks where the GPR180 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • late-onset Alzheimer disease
regulated by
  • interferon alpha
  • SNX27
  • Retromer
regulates
role in cell
  • differentiation
  • cell viability

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GPR180 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • G-protein coupled receptor signaling pathway
  • response to pheromone

Cellular Component

Where in the cell the gene product is active
  • membrane

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.