KPNA4 Gene Summary [Human]
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KPNA4 |
| Official Name | karyopherin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6397] |
| Ensembl ID | ENSG00000186432 |
| Bio databases IDs | |
| Aliases | karyopherin subunit alpha 4, importin alpha 3 |
| Synonyms | 1110058D08Rik, 9630025H16Rik, Imp alpha 3, importin, IMPORTIN-alpha3, importin α 3, Imp α 3, IPOA3, Karyopherin alpha4, karyopherin subunit alpha 4, karyopherin subunit α 4, LOC100507647, QIP1, SRP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KPNA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- Atypical Arm repeat
- HEAT-like repeat
- importin beta binding domain
- Armadillo/beta-catenin-like repeats
- coiled-coil domain
- protein binding
- Adaptin N terminal region
- nuclear localization sequence binding
Pathways
Biological processes and signaling networks where the KPNA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- cardiovascular disorder
- epithelial cancer
- metastasis
- bipolar disorder
- NPM1 mutation positive acute myeloid leukemia
- prostatic carcinoma
- infection by Orthomyxoviridae
- infection by HIV-1
role in cell
- formation in
- quantity
- cellular infiltration by
- migration
- abnormal morphology
- activation in
- aggregation in
- nuclear import in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nuclear envelope
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KPNA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine secretion
- protein import into nucleus
- NLS-bearing substrate import into nucleus
- gene expression
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytosol
- NLS-dependent protein nuclear import complex
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- nuclear localization sequence binding