CEBPG Gene Summary [Human]
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | CEBPG |
| Official Name | CCAAT enhancer binding protein gamma [Source:HGNC Symbol;Acc:HGNC:1837] |
| Ensembl ID | ENSG00000153879 |
| Bio databases IDs | |
| Aliases | CCAAT enhancer binding protein gamma |
| Synonyms | CCAAT enhancer binding protein gamma, CCAAT/enhancer binding protein gamma, CCAAT enhancer binding protein γ, CCAAT/enhancer binding protein γ, C/EBP, CEBP1 gamma, CEBP1 γ, C/EBP[g], C/EBPgamma, CEBPRNA, Cebp γ, GPE1-BP, Ig/EBP, IG/EBP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CEBPG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- DNA binding domain
- nucleic acid binding
- Basic region leucine zipper
- DNA bending protein
- transcription factor binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- double-stranded DNA binding
- bZIP
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the CEBPG gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute lung injury
- non-small cell lung cancer
- small cell lung cancer
- primary myelofibrosis
- lipopolysaccharide induced acute lung injury
- hemangioma
- angiomatosis
- systemic juvenile idiopathic arthritis
role in cell
- expression in
- differentiation
- development
- function
- remodeling
- quantity
- cytolysis by
- disassembly
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CEBPG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- B cell differentiation
- transcription, DNA-dependent
- enucleate erythrocyte differentiation
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of DNA binding
- natural killer cell mediated cytotoxicity
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of transcription from RNA polymerase II promoter
- immune response
- mRNA metabolic process
- liver development
- positive regulation of interferon-gamma production
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity