PROM2 Gene Summary [Human]
This gene encodes a member of the prominin family of pentaspan membrane glycoproteins. The encoded protein localizes to basal epithelial cells and may be involved in the organization of plasma membrane microdomains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | PROM2 |
| Official Name | prominin 2 [Source:HGNC Symbol;Acc:HGNC:20685] |
| Ensembl ID | ENSG00000155066 |
| Bio databases IDs | |
| Aliases | prominin 2 |
| Synonyms | prominin 2, PROML2, Prom-rp, Trprp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PROM2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prominin
- cholesterol binding
- protein binding
- transmembrane receptor
- Cdc37 N terminal kinase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- anemia
- idiopathic pulmonary fibrosis
role in cell
- cell death
- expression in
- proliferation
- accumulation in
- invasion by
- migration
- cisplatin sensitivity
- number
- pinocytosis by
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- extracellular vesicles
- cilia
- cell surface
- perinuclear region
- cellular membrane
- plasma membrane projections
- nuclear envelope
- cytoplasmic vesicles
- membrane rafts
- cellular protrusions
- microvilli
- microspikes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PROM2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of pinocytosis
- positive regulation of protein phosphorylation
- regulation of GTPase activity
- negative regulation of caveolin-mediated endocytosis
- regulation of clathrin-mediated endocytosis
- positive regulation of cell projection organization
Cellular Component
Where in the cell the gene product is active
- prominosome
- cell projection
- plasma membrane
- cell surface
- microvillus membrane
- microspike
- extracellular vesicular exosome
- microvillus
- membrane raft
- cilium
- cytoplasmic vesicle
- cilium membrane
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding