LAS1L Gene Summary [Human]
Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in membrane. Part of MLL1 complex. Implicated in Wilson-Turner syndrome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | LAS1L |
| Official Name | LAS1 like ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:25726] |
| Ensembl ID | ENSG00000001497 |
| Bio databases IDs | |
| Aliases | LAS1 like ribosome biogenesis factor |
| Synonyms | 1810030A06RIK, 5830482G23Rik, dJ475B7.2, FLJ12525, Las1, Las1-like, LAS1 like ribosome biogenesis factor, LAS1-like, ribosome biogenesis factor, LAS1-like (S. cerevisiae), MRXSWTS, RGD1565755, WTS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LAS1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Las1-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- Wilson-Turner X-linked mental retardation syndrome
- global developmental delay
- syndromic X-linked mental retardation
role in cell
- expression in
- proliferation
- autophagy in
- G1 phase
- processing in
- synthesis in
- biogenesis in
- biogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LAS1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of 5.8S rRNA
- maturation of LSU-rRNA
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- membrane
- nucleolus
- nucleoplasm
- MLL1 complex
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- endonuclease activity