TMBIM4 Gene Summary [Human]
Involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Located in Golgi stack. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMBIM4 |
| Official Name | transmembrane BAX inhibitor motif containing 4 [Source:HGNC Symbol;Acc:HGNC:24257] |
| Ensembl ID | ENSG00000155957 |
| Bio databases IDs | |
| Aliases | transmembrane BAX inhibitor motif containing 4 |
| Synonyms | 0610007H07Rik, CGI-119, GAAP, LFG4, LOC100133322, S1R, transmembrane BAX inhibitor motif containing 4, ZPRO |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMBIM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inhibitor of apoptosis-promoting Bax1
- BAX inhibitor (BI)-1/YccA-like protein family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cellular membrane
- Golgi Apparatus
- endoplasmic reticulum membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMBIM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- negative regulation of apoptotic process
- apoptotic process
- regulation of calcium-mediated signaling
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- Golgi stack
Molecular Function
What the gene product does at the molecular level
- protein binding