THOC5 Gene Summary [Human]
Predicted to enable mRNA binding activity. Involved in several processes, including monocyte differentiation; negative regulation of DNA damage checkpoint; and viral mRNA export from host cell nucleus. Located in nucleoplasm. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region. Implicated in breast carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | THOC5 |
| Official Name | THO complex 5 [Source:HGNC Symbol;Acc:HGNC:19074] |
| Ensembl ID | ENSG00000100296 |
| Bio databases IDs | |
| Aliases | THO complex 5, functional spliceosome-associated protein 79 |
| Synonyms | 1700060C24Rik, A430085L24RIK, C22orf19, FMIP, fSAP79, PK1.3, Sgk2, THO complex 5, THO complex subunit 5, TREX90 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human THOC5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fms binding domain
- cytoplasmic domain
- mRNA binding
- protein binding
- Fms-interacting protein/Thoc5
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
role in cell
- expression in
- morphology
- apoptosis
- differentiation
- survival
- alternative splicing in
- cell division
- morphogenesis
- number
- multinucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human THOC5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- RNA splicing
- mRNA processing
- monocyte differentiation
- primitive hemopoiesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- cytoplasm
- THO complex
- transcription export complex
- THO complex part of transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA binding