RPS6KA2 Gene Summary [Human]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | RPS6KA2 |
| Official Name | ribosomal protein S6 kinase A2 [Source:HGNC Symbol;Acc:HGNC:10431] |
| Ensembl ID | ENSG00000071242 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase A2 |
| Synonyms | D17Wsu134e, HU-2, IMAGE:4151609, MAPKAPK1C, p90rsk, p90-RSK2, p90-RSK3, pp90rsk, pp90RSK3, ribosomal protein S6 kinase A2, ribosomal protein S6 kinase, polypeptide 2, Rps6ka-rs1, RSK, RSK3, S6K-alpha, S6K-alpha2, S6K-α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS6KA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein threonine/tyrosine kinase
- Protein tyrosine and serine/threonine kinase
- AF-2 transcription activation domain
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- ribosomal protein S6 kinase
- PDZ binding motif
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the RPS6KA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- CNTF Signaling
- Eicosanoid Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Growth Hormone Signaling
- Melanocyte Development and Pigmentation Signaling
- MSP-RON Signaling Pathway
- mTOR Signaling
- NGF Signaling
- Opioid Signaling Pathway
- p38 MAPK Signaling
- RAR Activation
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- major depression
- acute myeloid leukemia
- pervasive developmental disorder
- bipolar disorder
- vascular dementia
- pulmonary edema
- cafe au lait spot
- familial adenomatous polyposis
- renal clear cell adenocarcinoma
role in cell
- expression in
- apoptosis
- phosphorylation in
- cell cycle progression
- proliferation
- number
- maturation
- cell viability
- senescence
- hypertrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spindle apparatus
- Cytoplasm
- cytosol
- nucleoplasm
- meiotic spindles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPS6KA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- positive regulation of apoptotic process
- negative regulation of cell cycle
- synaptic transmission
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ribosomal protein S6 kinase activity
- ATP binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- protein serine/threonine kinase activity