PIAS2 Gene Summary [Human]
This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | PIAS2 |
| Official Name | protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311] |
| Ensembl ID | ENSG00000078043 |
| Bio databases IDs | |
| Aliases | protein inhibitor of activated STAT 2, zinc finger, MIZ-type containing 4 |
| Synonyms | ARIP3, Dib, DIP, MIZ1, PIASX, PIASxalpha6, PIASxb, protein inhibitor of activated STAT 2, protein inhibitor of activated STAT, 2, SIZ2, ZMIZ4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIAS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SUMO ligase
- PINIT domain
- ubiquitin protein ligase binding
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- SUMO interaction motif
- SAP motif
- SUMO transferase activity
- nuclear localization sequence
- androgen receptor binding
- protein domain specific binding
- transcription factor binding
- estrogen receptor binding
- protein binding
- zinc binding domain
- proline rich domain
- DNA binding
- ring like zinc finger domain
- zinc ion binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
- serine threonine rich domain
- zinc finger domain
Pathways
Biological processes and signaling networks where the PIAS2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myeloproliferative neoplasm
- myeloproliferative disorder
- diabetic nephropathy
- pneumonia
- polycythemia vera
- Parkinson disease with dementia
- Parkinson disease
- natural killer/T-cell lymphoma
- T-cell non-Hodgkin disease
- natural killer cell neoplasia
role in cell
- apoptosis
- loss
- activation in
- growth
- differentiation
- transcription in
- sumoylation in
- ubiquitination in
- aggregation in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubules
- nucleoplasm
- nuclear bodies
- nuclear speckles
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIAS2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- protein sumoylation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of androgen receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein binding
- transcription cofactor activity
- ubiquitin protein ligase binding
- SUMO ligase activity