RPRD1B Gene Summary [Human]
Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in positive regulation of cell population proliferation; regulation of cell cycle process; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RPRD1B |
| Official Name | regulation of nuclear pre-mRNA domain containing 1B [Source:HGNC Symbol;Acc:HGNC:16209] |
| Ensembl ID | ENSG00000101413 |
| Bio databases IDs | |
| Aliases | regulation of nuclear pre-mRNA domain containing 1B, cell-cycle related and expression-elevated protein in tumor, Ku70-binding protein 5-Hera |
| Synonyms | 2610304G08Rik, 2810446G03Rik, C20orf77, CREPT, dJ1057B20.2, K-H, Kub5-Hera, NET60, regulation of nuclear pre-mRNA domain containing 1B, RGD1304782 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPRD1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil terminus domain
- VHS, ENTH and ANTH domain superfamily
- enzyme binding
- CID domain
- protein binding
- Cell-cycle alteration and expression-elevated protein in tumour
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- binding in
- expression in
- proliferation
- invasion by
- survival
- cohesion
- cohesion in
- signaling in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPRD1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- promoter clearance from RNA polymerase II promoter
- positive regulation of cell proliferation
- mRNA 3'-end processing
- positive regulation of transcription from RNA polymerase II promoter
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core binding