DUSP2 Gene Summary [Human]
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DUSP2 |
| Official Name | dual specificity phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:3068] |
| Ensembl ID | ENSG00000158050 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 2 |
| Synonyms | dual specificity phosphatase 2, PAC-1, PHOSPHATASE |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DUSP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- MAPK binding site
- protein tyrosine/threonine phosphatase
- Rhodanese Homology Domain
- protein binding
- Rhodanese-like domain
- PTP_DSP_cys
- RHOD
- Protein tyrosine phosphatase, catalytic domain motif
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the DUSP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- colorectal cancer
- chronic lymphocytic leukemia
- breast cancer
- atopic dermatitis
- epileptic seizure
- prostate cancer
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- phosphorylation in
- cell death
- apoptosis
- cell viability
- activation in
- pluripotency
- tumorigenicity
- function
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DUSP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- protein dephosphorylation
- endoderm formation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- MAP kinase tyrosine phosphatase activity
- protein tyrosine/threonine phosphatase activity
- protein tyrosine phosphatase activity
- mitogen-activated protein kinase binding
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity