Dusp2 Gene Summary [Mouse]
Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; dorsal root ganglion; and retina. Orthologous to human DUSP2 (dual specificity phosphatase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp2 |
| Official Name | dual specificity phosphatase 2 [Source:MGI Symbol;Acc:MGI:101911] |
| Ensembl ID | ENSMUSG00000027368 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 2 |
| Synonyms | dual specificity phosphatase 2, PAC-1, PHOSPHATASE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dusp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- MAPK binding site
- protein tyrosine/threonine phosphatase
- Rhodanese Homology Domain
- protein binding
- Rhodanese-like domain
- PTP_DSP_cys
- RHOD
- Protein tyrosine phosphatase, catalytic domain motif
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the Dusp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- colorectal cancer
- chronic lymphocytic leukemia
- breast cancer
- atopic dermatitis
- epileptic seizure
- prostate cancer
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- phosphorylation in
- cell death
- apoptosis
- cell viability
- activation in
- pluripotency
- tumorigenicity
- function
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dusp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
- protein dephosphorylation
- endoderm formation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- MAP kinase tyrosine phosphatase activity
- protein tyrosine/threonine phosphatase activity
- protein tyrosine phosphatase activity
- mitogen-activated protein kinase binding
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity