FCER1G Gene Summary [Human]
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | FCER1G |
| Official Name | Fc fragment of IgE receptor Ig [Source:HGNC Symbol;Acc:HGNC:3611] |
| Ensembl ID | ENSG00000158869 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgE receptor Ig, Fc epsilon receptor Ig, FcepsilonRI gamma chain |
| Synonyms | CD23, CD8 gamma, CD8 γ, Fce1g, Fc epsilon r1 gamma2, Fc epsilon receptor Ig, Fc epsilon R gamma, FcepsilonRI, Fcerg, FCERG1, FceRI gamma, FceRI γ, FC gamma receptor 1, Fc receptor, IgE, high affinity I, gamma polypeptide, Fc receptor, IgE, high affinity I, γ polypeptide, FCRG, FcR[g], FcR-gamma, FcR-γ, FC γ receptor 1, Fc ε r1 gamma2, Fc ε R1 γ, Fc ε receptor Ig, Fc ε R γ, gamma CHAIN, High affinity immunoglobulin ε receptor γ subunit, LOC498279, Ly-50, γ CHAIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCER1G often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signal response domain
- T-cell surface glycoprotein CD3 zeta chain
- protein binding
- IgE receptor
- identical protein binding
- IgG binding
- cytoplasmic domain
- transmembrane domain
- Immunoreceptor tyrosine-based activation motif
- intracellular domain
- protein homodimerization
- transmembrane receptor
- protein heterodimerization
- IgE binding
Pathways
Biological processes and signaling networks where the FCER1G gene in human plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Antiproliferative Role of TOB in T Cell Signaling
- Autoimmune Thyroid Disease Signaling
- Calcium-induced T Lymphocyte Apoptosis
- CCR5 Signaling in Macrophages
- Cdc42 Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Dendritic Cell Maturation
- Fc Epsilon RI Signaling
- G Protein Signaling Mediated by Tubby
- GP6 Signaling Pathway
- Graft-versus-Host Disease Signaling
- HER-2 Signaling in Breast Cancer
- Lipid Antigen Presentation by CD1
- Natural Killer Cell Signaling
- NF-κB Signaling
- Nur77 Signaling in T Lymphocytes
- OX40 Signaling Pathway
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- SAPK/JNK Signaling
- Systemic Lupus Erythematosus Signaling
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- osteopetrosis
- passive systemic anaphylaxis
- allergic rhinitis
- renal clear cell adenocarcinoma
- Alzheimer disease
- systemic lupus erythematosus
- insulin-dependent diabetes mellitus
- chronic myeloid leukemia
role in cell
- phosphorylation in
- activation
- cell death
- activation in
- apoptosis
- expression in
- production in
- proliferation
- growth
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- secretory granule membrane
- tertiary granule membrane
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCER1G gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-3-mediated signaling pathway
- T cell differentiation involved in immune response
- Fc-epsilon receptor signaling pathway
- neutrophil activation involved in immune response
- Fc-gamma receptor signaling pathway
- defense response to bacterium
- Fc receptor mediated stimulatory signaling pathway
- antigen processing and presentation of exogenous peptide antigen via MHC class I
- innate immune response
- immunoglobulin mediated immune response
- neutrophil chemotaxis
- positive regulation of phagocytosis
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- receptor internalization
- positive regulation of interleukin-4 production
- cellular response to low-density lipoprotein particle stimulus
- regulation of platelet activation
Cellular Component
Where in the cell the gene product is active
- Fc-gamma receptor III complex
- external side of plasma membrane
- Fc-epsilon receptor I complex
- tertiary granule membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- IgE binding
- IgG binding
- IgE receptor activity