STAP2 Gene Summary [Human]
This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STAP2 |
| Official Name | signal transducing adaptor family member 2 [Source:HGNC Symbol;Acc:HGNC:30430] |
| Ensembl ID | ENSG00000178078 |
| Bio databases IDs | |
| Aliases | signal transducing adaptor family member 2 |
| Synonyms | BKS, signal transducing adaptor family member 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STAP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- SH2 like domain
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- dextran sodium sulfate-induced colitis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- tumorigenesis
- kidney stones
- experimental autoimmune encephalomyelitis
role in cell
- apoptosis
- activation in
- degradation in
- phosphorylation in
- expression in
- survival
- binding in
- downregulation in
- quantity
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STAP2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity