WNT9B Gene Summary [Human]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | WNT9B |
| Official Name | Wnt family member 9B [Source:HGNC Symbol;Acc:HGNC:12779] |
| Ensembl ID | ENSG00000158955 |
| Bio databases IDs | |
| Aliases | Wnt family member 9B |
| Synonyms | clf, clf1, wingless-type MMTV integration site family, member 9B, WNT14B, WNT15, Wnt family member 9B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNT9B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- receptor agonist activity
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the WNT9B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- nonsyndromic cleft lip and palate
- prostate cancer
- hypoplasia
- hypertension
- prostatic carcinoma
- renal failure
- cleft lip
- developmental delay
- cleft palate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WNT9B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- palate development
- uterus morphogenesis
- collecting duct development
- response to retinoic acid
- kidney rudiment formation
- in utero embryonic development
- establishment of planar polarity involved in nephron morphogenesis
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- regulation of tube size
- neuron differentiation
- embryonic cranial skeleton morphogenesis
- regulation of asymmetric cell division
- cellular response to starvation
- cornea development in camera-type eye
- mesonephric duct formation
- metanephric tubule formation
- regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
- regulation of protein phosphorylation
- male genitalia development
- cellular response to retinoic acid
- branching involved in ureteric bud morphogenesis
- cell fate commitment
- mesenchymal stem cell maintenance involved in nephron morphogenesis
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- receptor agonist activity
- cytokine activity