OLIG2 Gene Summary [Human]
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | OLIG2 |
| Official Name | oligodendrocyte transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:9398] |
| Ensembl ID | ENSG00000205927 |
| Bio databases IDs | |
| Aliases | oligodendrocyte transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, protein kinase C binding protein 2, human protein kinase C-binding protein RACK17, basic domain, helix-loop-helix protein, class B, 1 |
| Synonyms | BHLHB1, bHLHe19, Olg-2, OLIGO2, oligodendrocyte transcription factor 2, PRKCBP2, RACK17, RK17 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OLIG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription repression domain
- double-stranded DNA binding
- helix loop helix domain
- serine threonine rich domain
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- T-lymphoblastic leukemia/lymphoma
- diabetic nephropathy
- medulloblastoma
- brain cancer
- lack of spontaneous movement
role in cell
- expression in
- differentiation
- quantity
- formation
- number
- production
- growth
- development
- generation
- patterning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OLIG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- neuron fate commitment
- negative regulation of neuron differentiation
- spinal cord motor neuron differentiation
- myelination
- positive regulation of transcription from RNA polymerase II promoter
- spinal cord oligodendrocyte cell fate specification
- thalamus development
- sensory organ development
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- HMG box domain binding
- identical protein binding
- protein binding
- protein dimerization activity
- E-box binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity