Wnt9b Gene Summary [Mouse]
Enables co-receptor binding activity and signaling receptor binding activity. Acts upstream of or within several processes, including Wnt signaling pathway; chordate embryonic development; and kidney development. Predicted to be located in extracellular region. Predicted to be part of Wnt-Frizzled-LRP5/6 complex. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; epithelium; genitourinary system; heart; and surface ectoderm. Orthologous to human WNT9B (Wnt family member 9B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnt9b |
| Official Name | wingless-type MMTV integration site family, member 9B [Source:MGI Symbol;Acc:MGI:1197020] |
| Ensembl ID | ENSMUSG00000018486 |
| Bio databases IDs | |
| Aliases | wingless-type MMTV integration site family, member 9B |
| Synonyms | clf, clf1, wingless-type MMTV integration site family, member 9B, WNT14B, WNT15, Wnt family member 9B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wnt9b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt
- wnt family
- receptor agonist activity
- protein binding
- receptor binding
- found in Wnt-1
Pathways
Biological processes and signaling networks where the Wnt9b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- Basal Cell Carcinoma Signaling
- Chronic Myeloid Leukemia Signaling
- Colorectal Cancer Metastasis Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Glioblastoma Multiforme Signaling
- Human Embryonic Stem Cell Pluripotency
- Molecular Mechanisms of Cancer
- Ovarian Cancer Signaling
- PCP pathway
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Transcriptional Regulatory Network in Embryonic Stem Cells
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- nonsyndromic cleft lip and palate
- prostate cancer
- hypoplasia
- hypertension
- prostatic carcinoma
- renal failure
- cleft lip
- developmental delay
- cleft palate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wnt9b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- palate development
- uterus morphogenesis
- collecting duct development
- response to retinoic acid
- kidney rudiment formation
- in utero embryonic development
- establishment of planar polarity involved in nephron morphogenesis
- canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway, planar cell polarity pathway
- regulation of tube size
- neuron differentiation
- embryonic cranial skeleton morphogenesis
- regulation of asymmetric cell division
- cellular response to starvation
- cornea development in camera-type eye
- mesonephric duct formation
- metanephric tubule formation
- regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
- regulation of protein phosphorylation
- male genitalia development
- cellular response to retinoic acid
- branching involved in ureteric bud morphogenesis
- cell fate commitment
- mesenchymal stem cell maintenance involved in nephron morphogenesis
- non-canonical Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- frizzled binding
- receptor agonist activity
- cytokine activity