IFNGR2 Gene Summary [Human]
This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IFNGR2 |
| Official Name | interferon gamma receptor 2 [Source:HGNC Symbol;Acc:HGNC:5440] |
| Ensembl ID | ENSG00000159128 |
| Bio databases IDs | |
| Aliases | interferon gamma receptor 2 |
| Synonyms | AF-1, IFGR2, Ifgt, IFNgammaRbeta, IFN gamma R beta 1, IFNGRB, IFNGT1, IFN γ R β 1, IMD28, interferon gamma receptor 2, interferon γ receptor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNGR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- interferon-gamma receptor
- FN3
- protein binding
- Fibronectin type 3 domain
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IFNGR2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- insulin-dependent diabetes mellitus
- COVID-19
- lung cancer
- pulmonary fibrosis
- inflammatory bowel disease
- peritoneal carcinoma
- antineutrophil cytoplasmic antibody-associated vasculitis
- paralytic autoimmune myositis
- infection
role in cell
- cytotoxicity
- function
- activation
- development
- differentiation
- class switching
- signaling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNGR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microglial cell activation
- interferon-gamma-mediated signaling pathway
- cytokine-mediated signaling pathway
- defense response to virus
- cell surface receptor signaling pathway
- response to virus
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasmic vesicle membrane
- endoplasmic reticulum
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-gamma receptor activity
- cytokine receptor activity