PTGDR Gene Summary [Human]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | PTGDR |
| Official Name | prostaglandin D2 receptor [Source:HGNC Symbol;Acc:HGNC:9591] |
| Ensembl ID | ENSG00000168229 |
| Bio databases IDs | |
| Aliases | prostaglandin D2 receptor |
| Synonyms | AS1, ASRT1, DP, DP1, Dp1r, Dp2, DP-R, LOC100365135, PGD, PGD2 receptor, prostaglandin D2 receptor, prostaglandin D receptor, PTGDR1, Ptgdr2, Ptgdrl |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGDR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin receptor
- extracellular domain
- prostaglandin D receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGDR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- dyslipidemia
- cardiovascular disorder
- hypercholesterolemia
- hypersensitivity reaction type I
- mixed dyslipidemia
- mixed hyperlipidemia
- vasomotor rhinitis
- primary hypercholesterolemia
- hyperlipidemia
role in cell
- activation in
- chemotaxis
- migration
- expression in
- transendothelial migration
- activation
- function
- phosphorylation in
- number
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- vesicles
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGDR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male sex determination
- inflammatory response
- adenosine metabolic process
- G-protein coupled receptor signaling pathway
- cellular response to prostaglandin D stimulus
- sleep
- mast cell degranulation
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- prostaglandin J receptor activity
- protein binding
- prostaglandin D receptor activity