SCUBE1 Gene Summary [Human]
This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | SCUBE1 |
| Official Name | signal peptide, CUB domain and EGF like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:13441] |
| Ensembl ID | ENSG00000159307 |
| Bio databases IDs | |
| Aliases | signal peptide, CUB domain and EGF like domain containing 1 |
| Synonyms | 7330410C13Rik, A630023E24Rik, FLJ30901, signal peptide, CUB domain and EGF like domain containing 1, signal peptide, CUB domain, EGF-like 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCUBE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- CUB
- Tyrosine-protein kinase ephrin type A/B receptor-like
- calcium ion binding
- EGF domain
- protein binding
- identical protein binding
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- peripheral neuropathy
- organismal death
- colorectal cancer
- Parkinson disease
- coronary artery disease
- inflammatory bowel disease
- laser induced choroidal neovascularization
role in cell
- expression in
- invasion by
- cell viability
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCUBE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- positive regulation of smoothened signaling pathway
- post-embryonic development
- endothelial cell differentiation
- blood coagulation
- adult heart development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding