PADI4 Gene Summary [Human]
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PADI4 |
| Official Name | peptidyl arginine deiminase 4 [Source:HGNC Symbol;Acc:HGNC:18368] |
| Ensembl ID | ENSG00000159339 |
| Bio databases IDs | |
| Aliases | peptidyl arginine deiminase 4 |
| Synonyms | PAD, PAD4, PAD5, PADI5, PDI4, PDI5, peptidyl arginine deiminase 4, peptidyl arginine deiminase, type IV |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PADI4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-arginine deiminase
- Protein-arginine deiminase (PAD) N-terminal domain
- Cupredoxin superfamily
- catalytic domain
- Protein-arginine deiminase (PAD)
- immunoglobulin-like protein domain
- calcium ion binding
- enzyme
- Protein-arginine deiminase (PAD) middle domain
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection
- IgA nephropathy
- cerebral hemorrhage
- cardiac fibrosis
- pulmonary fibrosis
- organismal death
- vascular leak syndrome
- prolactinoma
- adenoma formation
role in cell
- apoptosis
- growth
- expression in
- proliferation
- cellular infiltration by
- number
- formation
- formation in
- assembly
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PADI4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- chromatin remodeling
- stem cell maintenance
- innate immune response
- chromatin organization
- post-translational protein modification
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein-arginine deiminase activity
- protein binding
- calcium ion binding