CXCR5 Gene Summary [Human]
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | CXCR5 |
| Official Name | C-X-C motif chemokine receptor 5 [Source:HGNC Symbol;Acc:HGNC:1060] |
| Ensembl ID | ENSG00000160683 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine receptor 5 |
| Synonyms | BLR1, Burkitt lymphoma receptor 1, Burkitts lymphoma receptor 1, CD185, C-X-C motif chemokine receptor 5, Gpcr6, MDR15, NLR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CXCR5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Pathways
Biological processes and signaling networks where the CXCR5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- multiple sclerosis
- seizures
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- rheumatoid arthritis
- inflammatory bowel disease
- insulin-dependent diabetes mellitus
- hydronephrosis
- Sjögren syndrome
- extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
role in cell
- expression in
- quantity
- activation in
- migration
- mobilization in
- chemotaxis
- cellular infiltration by
- differentiation
- signaling in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CXCR5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- G-protein coupled receptor signaling pathway
- chemokine-mediated signaling pathway
- lymph node development
- leukocyte chemotaxis
- B cell activation
- calcium-mediated signaling
- positive regulation of cytokinesis
- cell chemotaxis
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- G-protein coupled receptor activity
- protein binding
- C-C chemokine receptor activity
- C-X-C chemokine receptor activity