IER2 Gene Summary [Human]
Predicted to enable DNA binding activity. Involved in cell motility and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IER2 |
| Official Name | immediate early response 2 [Source:HGNC Symbol;Acc:HGNC:28871] |
| Ensembl ID | ENSG00000160888 |
| Bio databases IDs | |
| Aliases | immediate early response 2 |
| Synonyms | Ch1, CHX1, ETR101, ETR11, Growth factor-inducible, immediate early response 2, Pip92, T lymphocyte activated |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IER2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- organismal death
- breast cancer
- COVID-19
- psoriasis
- Ullrich congenital muscular dystrophy
- venous thromboembolism
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
- SPP1
role in cell
- senescence
- differentiation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IER2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- neuron differentiation
- response to fibroblast growth factor stimulus
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding