DHX33 Gene Summary [Human]
This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | DHX33 |
| Official Name | DEAH-box helicase 33 [Source:HGNC Symbol;Acc:HGNC:16718] |
| Ensembl ID | ENSG00000005100 |
| Bio databases IDs | |
| Aliases | DEAH-box helicase 33 |
| Synonyms | 3110057P17Rik, 9430096J02Rik, DDX33, DEAH-box helicase 33 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHX33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helicase associated domain (HA2)
- Oligonucleotide/oligosaccharide-binding (OB)-fold
- mRNA binding
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- transcription factor binding
- enzyme
- ribosomal DNA (rDNA) binding protein
- protein binding
- Helicase conserved C-terminal domain
- Helicase associated domain (HA2) Add an annotation
- double-stranded RNA binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
- ribosomal large subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHX33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of type I interferon production
- positive regulation of MAPK cascade
- positive regulation of NLRP3 inflammasome complex assembly
- translational initiation
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- intracellular
- NLRP3 inflammasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity
- double-stranded RNA binding
- rDNA binding
- mRNA binding
- ribosomal large subunit binding
- helicase activity