RPS6KA4 Gene Summary [Human]
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | RPS6KA4 |
| Official Name | ribosomal protein S6 kinase A4 [Source:HGNC Symbol;Acc:HGNC:10433] |
| Ensembl ID | ENSG00000162302 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase A4 |
| Synonyms | 1110069D02Rik, Ccdc88b, KS6A4, LOC684803, mMSK2, MSK2, ribosomal protein S6 kinase A4, ribosomal protein S6 kinase, polypeptide 4, RSK-B, S6K-alpha-4, S6K-α-4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RPS6KA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- enzyme
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the RPS6KA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
- CNTF Signaling
- ERK/MAPK Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Growth Hormone Signaling
- ILK Signaling
- Melanocyte Development and Pigmentation Signaling
- mTOR Signaling
- NGF Signaling
- Opioid Signaling Pathway
- p38 MAPK Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- systemic lupus erythematosus
- insulin-dependent diabetes mellitus
- endotoxin shock response
- hypoplasia
- overall survival
- eczema
- leprosy
- idiopathic scoliosis
- primary biliary cirrhosis
role in cell
- activation in
- proliferation
- expression in
- upregulation in
- phosphorylation in
- survival
- number
- growth
- production in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RPS6KA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- post-translational protein modification
- inflammatory response
- chromatin remodeling
- interleukin-1-mediated signaling pathway
- positive regulation of CREB transcription factor activity
- peptidyl-serine phosphorylation
- negative regulation of cytokine production
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribosomal protein S6 kinase activity
- magnesium ion binding
- ATP binding
- protein binding
- histone kinase activity (H3-S10 specific)
- histone kinase activity (H3-S28 specific)
- protein serine/threonine kinase activity