ST13 Gene Summary [Human]
The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | ST13 |
| Official Name | ST13 Hsp70 interacting protein [Source:HGNC Symbol;Acc:HGNC:11343] |
| Ensembl ID | ENSG00000100380 |
| Bio databases IDs | |
| Aliases | ST13 Hsp70 interacting protein, progesterone receptor-associated p48 protein |
| Synonyms | 1110007I03RIK, 3110002K08RIK, AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, NA+,K+ atpase 1, P48, PRO0786, SNC6, ST13 Hsp70 interacting protein, ST13, Hsp70 interacting protein, suppression of tumorigenicity 13, suppression of tumourigenicity 13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ST13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hip_N
- TPR repeat
- Hsp70 protein binding
- nucleotide binding
- GGMP repeat domain
- protein binding activity, bridging
- homo-oligomerization domain
- protein domain specific binding
- STI1 domain
- protein binding
- purine nucleotide binding
- identical protein binding
- hsp70 binding domain
- binding protein
- Tetratricopeptide repeats
- adenyl nucleotide binding
- chaperone binding
- tetratricopeptide repeat
- charged domain
Pathways
Biological processes and signaling networks where the ST13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- abdominal aortic aneurysm
- immunodeficiency
- glioblastoma
- glioblastoma cancer
role in cell
- expression in
- apoptosis
- activation in
- phosphorylation in
- proliferation
- size
- differentiation
- chemotaxis
- maturation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ST13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- chaperone mediated protein folding requiring cofactor
- protein folding
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein dimerization activity
- protein binding, bridging
- Hsp70 protein binding