S100A11 Gene Summary [Human]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | S100A11 |
| Official Name | S100 calcium binding protein A11 [Source:HGNC Symbol;Acc:HGNC:10488] |
| Ensembl ID | ENSG00000163191 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A11, calgizzarin |
| Synonyms | cal, Calgizzarin, calizzarin, Emap1, EMAPI, HEL-S-43, MLN70, S100a14, S100C, S100 calcium binding protein A11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S100A11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- S-100/ICaBP type calcium binding domain
- EF-hand domain pair
- EF hand
- protein homodimerization
- EFh
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- abdominal cancer
- epithelial neoplasia
- digestive system cancer
- cancer
- liver cancer
- organismal death
- venous malformation
- atopic dermatitis
- Duchenne muscular dystrophy
role in cell
- apoptosis
- expression in
- phosphorylation in
- formation
- formation in
- growth
- proliferation
- migration
- invasion by
- mesenchymal epithelial transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- ruffle
- secretory granule lumen
- Extracellular Space
- Nucleus
- Mitochondria
- nucleoli
- pseudopodia
- filopodia
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S100A11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- negative regulation of DNA replication
- positive regulation of smooth muscle cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- adherens junction
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- ruffle
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- calcium ion binding
- calcium-dependent protein binding
- S100 protein binding