NEK10 Gene Summary [Human]
Enables protein kinase activity. Involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Part of protein kinase complex. Implicated in primary ciliary dyskinesia 44. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NEK10 |
| Official Name | NIMA related kinase 10 [Source:HGNC Symbol;Acc:HGNC:18592] |
| Ensembl ID | ENSG00000163491 |
| Bio databases IDs | |
| Aliases | NIMA related kinase 10 |
| Synonyms | CILD44, FLJ32685, Gm282, NIMA (never in mitosis gene a)- related kinase 10, NIMA-related kinase 10, RGD1564342 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NEK10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- breast cancer
- cancer
- breast carcinoma
- primary ciliary dyskinesia type 44
- estrogen receptor positive breast cancer
- late-onset Alzheimer disease
- cataract
- rotator cuff injury
- hypertrophic cardiomyopathy
regulated by
- bisphenol A
- Exendin4
role in cell
- expression in
- phosphorylation in
- proliferation
- growth
- cisplatin sensitivity
- tumorsphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NEK10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- regulation of ERK1 and ERK2 cascade
- positive regulation of protein autophosphorylation
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity