CDCP1 Gene Summary [Human]
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | CDCP1 |
| Official Name | CUB domain containing protein 1 [Source:HGNC Symbol;Acc:HGNC:24357] |
| Ensembl ID | ENSG00000163814 |
| Bio databases IDs | |
| Aliases | CUB domain containing protein 1 |
| Synonyms | 9030022E12Rik, CD318, CUB domain containing protein 1, E030027H19Rik, RGD1305578, SIMA135, TRASK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDCP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Src binding domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- metastasis
- advanced cancer
- cancer
- HER2 negative hormone receptor negative breast cancer
- tumorigenesis
- myopathy
- organismal death
- chronic myeloid leukemia
role in cell
- proliferation
- apoptosis
- activation in
- adhesion
- expression in
- migration
- growth
- phosphorylation in
- motility
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- cell-cell contacts
- apical cell surfaces
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDCP1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding