MEAF6 Gene Summary [Human]
This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | MEAF6 |
| Official Name | MYST/Esa1 associated factor 6 [Source:HGNC Symbol;Acc:HGNC:25674] |
| Ensembl ID | ENSG00000163875 |
| Bio databases IDs | |
| Aliases | MYST/Esa1 associated factor 6, Esa1p-associated factor 6 homolog (S. cerevisiae), centromere protein 28 |
| Synonyms | 2310005N01Rik, 2810036M01Rik, C1orf149, CENP-28, EAF6, FLJ11730, MYST/Esa1-associated factor 6, NY-SAR-91, RGD1310440 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEAF6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase
- Histone acetyltransferase subunit NuA4
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleosomes
- nucleoplasm
- nucleoli
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEAF6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of developmental process
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of double-strand break repair
- regulation of cell growth
- regulation of DNA biosynthetic process
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of DNA replication
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- NuA4 histone acetyltransferase complex
- MOZ/MORF histone acetyltransferase complex
- kinetochore
- nucleosome
- nucleolus
- histone acetyltransferase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone acetyltransferase activity (H4-K8 specific)
- histone acetyltransferase activity (H4-K5 specific)
- histone acetyltransferase activity (H4-K12 specific)