Polr2h Gene Summary [Mouse]
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of nuclear DNA-directed RNA polymerase complex and protein-DNA complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR2H (RNA polymerase II, I and III subunit H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr2h |
| Official Name | polymerase (RNA) II (DNA directed) polypeptide H [Source:MGI Symbol;Acc:MGI:2384309] |
| Ensembl ID | ENSMUSG00000021018 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) II (DNA directed) polypeptide H |
| Synonyms | LOC100912534, polymerase (RNA) II (DNA directed) polypeptide H, RGD1561203, RNA polymerase II, I and III subunit H, RPABC3, RPB17, RPB8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr2h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- DNA-directed RNA polymerase
- enzyme
- DNA-directed RNA polymerase, subunit G
- RNA polymerase Rpb8
Pathways
Biological processes and signaling networks where the Polr2h gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- productive infection by HIV-1
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- POLR2H
role in cell
- replication in
- growth
- cell death
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr2h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- protein-DNA complex
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- RNA polymerase III activity
- RNA polymerase II activity
- RNA polymerase I activity
- single-stranded DNA binding