EMCN Gene Summary [Human]
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | EMCN |
| Official Name | endomucin [Source:HGNC Symbol;Acc:HGNC:16041] |
| Ensembl ID | ENSG00000164035 |
| Bio databases IDs | |
| Aliases | endomucin |
| Synonyms | 0610012K22Rik, EMCN2, endomucin, MUC14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EMCN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Endomucin
- protein binding
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ischemic stroke
- non-small cell lung cancer
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
- COVID-19
- open-angle glaucoma
- insomnia
- uterine leiomyoma
role in cell
- adhesion
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EMCN gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane