SRPRA Gene Summary [Human]
The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Details
| Type | Protein Coding |
| Official Symbol | SRPRA |
| Official Name | SRP receptor subunit alpha [Source:HGNC Symbol;Acc:HGNC:11307] |
| Ensembl ID | ENSG00000182934 |
| Bio databases IDs | |
| Aliases | SRP receptor subunit alpha |
| Synonyms | 1300011P19RIK, D11Mgi27, Docking protein alpha, Docking protein α, DP, signal recognition particle receptor alpha, signal recognition particle receptor α, Sr alpha, SRPR, SRP receptor, SRP receptor subunit alpha, SRP receptor subunit α, Sr α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRPRA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CobQ/CobB/MinD/ParA nucleotide binding domain
- SRP54-type protein, GTPase domain
- SRP54-type protein, helical bundle domain
- protein binding
- Signal recognition particle, alpha subunit, N-terminal
- Longin-like domains
- P-loop containing Nucleoside Triphosphate Hydrolases
- signal recognition particle-docking protein FtsY
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Mitochondria
- endoplasmic reticulum membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRPRA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
- protein targeting to ER
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- membrane
- signal recognition particle receptor complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATPase activity
- RNA binding
- GTPase activity
- signal recognition particle binding