TCF15 Gene Summary [Human]
The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TCF15 |
| Official Name | transcription factor 15 [Source:HGNC Symbol;Acc:HGNC:11627] |
| Ensembl ID | ENSG00000125878 |
| Bio databases IDs | |
| Aliases | transcription factor 15 |
| Synonyms | bHLHa40, BHLH-EC2, EC2, Meso1, PARAXIS, transcription factor 15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCF15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- transcription factor binding
- helix-loop-helix domain
- Helix-loop-helix DNA-binding domain
- sequence-specific DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the TCF15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyspnea
- aphagia
role in cell
- hypertrophy
- differentiation
- organization
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCF15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesenchymal to epithelial transition
- stem cell maintenance
- mesoderm development
- paraxial mesoderm development
- muscle organ morphogenesis
- positive regulation of transcription from RNA polymerase II promoter
- skeletal system morphogenesis
- regulation of transcription from RNA polymerase II promoter
- positive regulation of stem cell differentiation
- respiratory system process
- neuromuscular process controlling posture
- somitogenesis
- ear development
- establishment of epithelial cell apical/basal polarity
- developmental process
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- E-box binding
- bHLH transcription factor binding