LIPC Gene Summary [Human]
Enables phospholipase A1 activity and triglyceride lipase activity. Involved in several processes, including lipid homeostasis; plasma lipoprotein particle remodeling; and triglyceride catabolic process. Located in extracellular space. Implicated in several diseases, including Alzheimer's disease; coronary artery disease; familial combined hyperlipidemia; peripheral vascular disease; and type 2 diabetes mellitus. Biomarker of hyperinsulinism; obesity; and type 1 diabetes mellitus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LIPC |
| Official Name | lipase C, hepatic type [Source:HGNC Symbol;Acc:HGNC:6619] |
| Ensembl ID | ENSG00000166035 |
| Bio databases IDs | |
| Aliases | lipase C, hepatic type, Triacylglycerol lipase |
| Synonyms | HDLCQ12, Hepatic Lipase, Hepatic Triglyceride Lipase, Hepatolipase, HL, Hpl, HTGL, lipase C, hepatic type, lipase, hepatic, LIPH, Triacylglycerol Lipase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LIPC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding
- lysophospholipase
- phospholipase A1
- alpha/beta hydrolases
- enzyme
- low-density lipoprotein binding
- protein binding
- lipoprotein lipase
- Lipoxygenase homology 2 (beta barrel) domain
- identical protein binding
- transferase, transferring acyl groups
- phospholipase
- triacylglycerol lipase
- acetylesterase
- binding protein
- acylglycerol lipase
- PLAT
- lipase
- heparin binding
Pathways
Biological processes and signaling networks where the LIPC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- schizophrenia
- epithelial cancer
- hepatic steatosis
- late-onset noninsulin-dependent diabetes mellitus
- organismal death
- hepatocellular carcinoma
- liver cancer
- idiopathic scoliosis
- coronary artery disease
role in cell
- migration
- number
- expression in
- proliferation
- synthesis in
- phosphorylation in
- size
- binding
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- endoplasmic reticulum lumen
- early endosomes
- late endosomes
- extracellular matrix
- microvilli
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LIPC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- very-low-density lipoprotein particle remodeling
- chylomicron remnant clearance
- high-density lipoprotein particle remodeling
- low-density lipoprotein particle remodeling
- intermediate-density lipoprotein particle remodeling
- cholesterol metabolic process
- fatty acid biosynthetic process
- cholesterol homeostasis
- phosphatidylcholine catabolic process
- reverse cholesterol transport
- triglyceride catabolic process
- triglyceride homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- high-density lipoprotein particle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- apolipoprotein binding
- lysophospholipase activity
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity
- protein binding
- phosphatidylserine 1-acylhydrolase activity
- triglyceride lipase activity
- heparin binding
- phosphatidylcholine 1-acylhydrolase activity
- low-density lipoprotein particle binding
- lipoprotein lipase activity
- phospholipase activity