ATMIN Gene Summary [Human]
Enables dynein complex binding activity. Involved in positive regulation of transcription, DNA-templated. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ATMIN |
| Official Name | ATM interactor [Source:HGNC Symbol;Acc:HGNC:29034] |
| Ensembl ID | ENSG00000166454 |
| Bio databases IDs | |
| Aliases | ATM interactor, ATM/ATR-Substrate Chk2-Interacting Zn++-finger protein, ATM INteracting protein |
| Synonyms | ASCIZ, ATM interactor, gpg6, KIAA0431, mKIAA0431, RGD1305781, ZNF822 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ATMIN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- binding protein
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the ATMIN gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung cancer
- organismal death
- exencephaly
- glioma formation
- glioma
role in cell
- expression in
- proliferation
- function
- apoptosis
- survival
- damage in
- sensitivity
- replicative senescence
- regeneration
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- soluble fraction
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ATMIN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- positive regulation of gene expression
- motile cilium assembly
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- dynein complex binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity